Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells.

Despite androgen deprivation therapy (ADT), persistent androgen receptor (AR) signaling enables outgrowth of castration resistant prostate cancer (CRPC). In prostate cancer (PCa) cells, ADT may enhance AR activity through induction of oxidative stress. Herein, we investigated the roles of Nrf1 and N...

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Bibliografiske detaljer

Principais autores:	Michelle A Schultz, Sharika S Hagan, Amrita Datta, Yiguo Zhang, Michael L Freeman, Suresh C Sikka, Asim B Abdel-Mageed, Debasis Mondal
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2014-01-01
Serier:	PLoS ONE
Online adgang:	http://europepmc.org/articles/PMC3899380?pdf=render
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