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Increased remodeling of type XXII collagen is associated with an inflammatory phenotype in Crohn’s disease

Abstract In Crohn’s disease, extracellular matrix (ECM) dysfunction and loss of tissue integrity are key pathological features. Fibril-associated collagens with interrupted triple helices (FACIT) are known to regulate ECM assembly and mediate biophysical cues in their microenvironment but remain lar...

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Principais autores: Marta S. Alexdottir, Arno R. Bourgonje, Thomai Tsapanou-Katranara, Martin Pehrsson, Line E. Godskesen, Roberta Loveikyte, Marijn C. Visschedijk, Eleonora A. M. Festen, Rinse K. Weersma, Anne-Christine Bay-Jensen, Morten A. Karsdal, Aleksander Krag, Jens Kjeldsen, Gerard Dijkstra, Joachim H. Mortensen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2026-04-01
coleção:Scientific Reports
Acesso em linha:https://doi.org/10.1038/s41598-026-49152-4
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