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Increased remodeling of type XXII collagen is associated with an inflammatory phenotype in Crohn’s disease

Abstract In Crohn’s disease, extracellular matrix (ECM) dysfunction and loss of tissue integrity are key pathological features. Fibril-associated collagens with interrupted triple helices (FACIT) are known to regulate ECM assembly and mediate biophysical cues in their microenvironment but remain lar...

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Autori principali: Marta S. Alexdottir, Arno R. Bourgonje, Thomai Tsapanou-Katranara, Martin Pehrsson, Line E. Godskesen, Roberta Loveikyte, Marijn C. Visschedijk, Eleonora A. M. Festen, Rinse K. Weersma, Anne-Christine Bay-Jensen, Morten A. Karsdal, Aleksander Krag, Jens Kjeldsen, Gerard Dijkstra, Joachim H. Mortensen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2026-04-01
Serie:Scientific Reports
Accesso online:https://doi.org/10.1038/s41598-026-49152-4
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