CDKN2A deletion is associated with immune desertification in diffuse pleural mesothelioma

Abstract Introduction Diffuse Pleural Mesothelioma (DPM) is a rare and incurable cancer. Immune checkpoint inhibitors (ICIs) marked some advances but only for a limited fraction of patients. Improving response prediction to ICIs is currently a clinical need in DPM. Deletion of CDKN2A gene, in chr9p2...

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Autors principals: Federica Torricelli, Benedetta Donati, Veronica Manicardi, Mila Gugnoni, Francesca Reggiani, Gloria Manzotti, Pierluigi Di Chiaro, Cristian Ascione, Simonetta Piana, Riccardo Valli, Roberto Piro, Massimiliano Paci, Nicola Facciolongo, Filippo Lococo, Alessia Ciarrocchi
Format: Artigo
Idioma:Inglês
Publicat: BMC 2025-08-01
Col·lecció:Journal of Experimental & Clinical Cancer Research
Matèries:
Diffuse pleural mesothelioma
Tumor immune microenvironment
Genetic alteration
CDKN2A
Immunotherapy
Accés en línia:https://doi.org/10.1186/s13046-025-03522-4
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