Targeting platelet-tumor cell interactions via thromboxane A2-prostanoid receptor blockade to reduce metastasis in triple negative breast cancer

Abstract In addition to their central role in blood hemostasis, it is increasingly clear that platelets contribute to multiple steps in the metastatic cascade. Platelets are one of the most abundant cells with which tumor cells interact once they enter the circulation, and the interaction of platele...

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Главные авторы: Veeresh Toragall, Ann C. Rester, Salma Begum, Oluwaseyi T. Shofolawe-Bakare, Kenneth Hulugalla, Jerry D. Monroe, John P. Bentley, Yann Gibert, Thomas A. Werfel
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2025-11-01
Серии:Experimental Hematology & Oncology
Предметы:
Ifetroban
Platelet activation
Thromboxane receptor and antimetastatic efficacy
Online-ссылка:https://doi.org/10.1186/s40164-025-00723-7
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