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Immunophenotyping TCF1-expressing TILs: spatial profiling and prognostic value in operable non-small cell lung cancer

BackgroundThe spatial distribution and functional heterogeneity of tumor-infiltrating lymphocytes (TILs) significantly impact patient outcomes in non-small cell lung cancer (NSCLC). While T cell factor 1 (TCF1) expressing TILs have emerged as key players in sustaining anti-tumor immunity, their subs...

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Principais autores: Konstantinos Ntostoglou, Georgios Christodoulopoulos, Katie Stoker, Jean Descarpentrie, Anastasia Xagara, Dora Chatzidaki, Vasiliki Anastasopoulou, Ilias P. Nikas, Argyro Ioanna Ieronimaki, Lucy Booth, Sophia Tsoka, Ioannis Vamvakaris, Apostolos Klinakis, Eleni Patsea, Sophia N. Karagiannis, Ioannis G. Panayiotides, Teresa Frisan, Vassilis Georgoulias, Athanasios Kotsakis, Ioannis S. Pateras
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-01-01
Serier:Frontiers in Immunology
Fag:
biomarkers
non-small cell lung cancer
spatial analysis
T cell factor 1
tumor infiltrating lymphocytes
tumor microenvironment
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1731337/full
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