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Quercetin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and activation of JAK2/STAT3 pathway: A target based networking pharmacology approach

The rapid growth of vascular smooth muscle cells (VSMCs) represents crucial pathological changes during the development of hypertensive vascular remodeling. Although quercetin exhibits significantly therapeutic effects on antihypertension, the systematic role of quercetin and its exact mode of actio...

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Principais autores: Di Wang, Farman Ali, Huixin Liu, Ying Cheng, Meizhu Wu, Muhammad Zubair Saleem, Huifang Zheng, Lihui Wei, Jiangfeng Chu, Qiurong Xie, Aling Shen, Jun Peng
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-10-01
Serier:Frontiers in Pharmacology
Fag:
networking pharmacology
JAK2
quercetin
vascular smooth muscle cells
stat3
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2022.1002363/full
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