Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma
<p>Abstract</p> <p>Background</p> <p>Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of cell proliferation and induction of apoptosis. Howeve...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BMC
2011-08-01
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| Col·lecció: | Journal of Experimental & Clinical Cancer Research |
| Matèries: | |
| Accés en línia: | http://www.jeccr.com/content/30/1/74 |
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