miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

Background Translocation of miR‐181c into cardiac mitochondria downregulates the mitochondrial gene, mt‐COX1. miR‐181c/d−/− hearts experience less oxidative stress during ischemia/reperfusion (I/R) and are protected against I/R injury. Additionally, miR‐181c overexpression can increase mitochondrial...

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Auteurs principaux:	Hemanth N. Banavath, Barbara Roman, Nathan Mackowski, Debjit Biswas, Junaid Afzal, Yohei Nomura, Soroosh Solhjoo, Brian O'Rourke, Mark Kohr, Elizabeth Murphy, Charles Steenbergen, Samarjit Das
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2019-12-01
Collection:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Sujets:	microRNA miRNA mitochondria mitomiR mitochondrial calcium heart failure
Accès en ligne:	https://www.ahajournals.org/doi/10.1161/JAHA.119.012919
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