Esculetin releases maturation arrest and induces terminal differentiation in leukemic blast cells by altering the Wnt signaling axes

Abstract Background The “Differentiation therapy” has been emerging as a promising and more effective strategy against acute leukemia relapses. Objective In extension to the revolutionising therapeutic outcomes of All Trans Retinoic Acid (ATRA) to induce terminal differentiation of Acute Promyelocyt...

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Autors principals:	Ankit Mathur, Aman Gangwar, Daman Saluja
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2023-05-01
Col·lecció:	BMC Cancer
Matèries:	Acute Myeloid Leukemia (AML) Esculetin Blast cell differentiation Differentiation therapy Kasumi-1 Wnt signaling
Accés en línia:	https://doi.org/10.1186/s12885-023-10818-1
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