Binding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurements.
Predicting off-targets by computational methods is getting increasing importance in early drug discovery stages. We herewith present a computational method based on binding site three-dimensional comparisons, which prompted us to investigate the cross-reaction of protein kinase inhibitors with synap...
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| Автори: | , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Public Library of Science (PLoS)
2010-08-01
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| Серія: | PLoS ONE |
| Онлайн доступ: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012214&type=printable |
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