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Bax-inhibitor-1 knockdown phenotypes are suppressed by Buffy and exacerbate degeneration in a Drosophila model of Parkinson disease

Background Bax inhibitor-1 (BI-1) is an evolutionarily conserved cytoprotective transmembrane protein that acts as a suppressor of Bax-induced apoptosis by regulation of endoplasmic reticulum stress-induced cell death. We knocked down BI-1 in the sensitive dopa decarboxylase (Ddc) expressing neurons...

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Principais autores: P. Githure M’Angale, Brian E. Staveley
פורמט: Artigo
שפה:Inglês
יצא לאור: PeerJ Inc. 2017-02-01
סדרה:PeerJ
נושאים:
Bax inhibitor-1
Buffy
Drosophila melanogaster
Model of Parkinson disease
α-synuclein
גישה מקוונת:https://peerj.com/articles/2974.pdf
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