Multifunctional and endogenous stimuli-responsive vinblastine sulfate/manganese dioxide nanodrugs for enhancing chemotherapeutic efficacy against hypoxic tumors

Several solid tumors contain large hypoxic regions, diminishing drug responses and resulting in limited therapeutic outcomes. Vinblastine sulfate (VBL) targets the tubulin molecule, causing microtubule depolymerization and inducing mitotic arrest, leading to tumor regression. However, hypoxia causes...

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Үндсэн зохиолчид:	Yong Geun Lim, Yeji Chang, Seon-Ju Park, Kyoung-Dong Kim, Kyeongsoon Park
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2025-10-01
Цуврал:	Materials Today Bio
Нөхцлүүд:	Vinblastine sulfate (VBL) Manganese dioxide (MnO2) Oxygen-generating materials Tumor microenvironment (TME) Tumor hypoxia relief Chemotherapy
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2590006425007999
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!