Multifunctional and endogenous stimuli-responsive vinblastine sulfate/manganese dioxide nanodrugs for enhancing chemotherapeutic efficacy against hypoxic tumors

Several solid tumors contain large hypoxic regions, diminishing drug responses and resulting in limited therapeutic outcomes. Vinblastine sulfate (VBL) targets the tubulin molecule, causing microtubule depolymerization and inducing mitotic arrest, leading to tumor regression. However, hypoxia causes...

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Detaylı Bibliyografya

Asıl Yazarlar:	Yong Geun Lim, Yeji Chang, Seon-Ju Park, Kyoung-Dong Kim, Kyeongsoon Park
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Elsevier 2025-10-01
Seri Bilgileri:	Materials Today Bio
Konular:	Vinblastine sulfate (VBL) Manganese dioxide (MnO2) Oxygen-generating materials Tumor microenvironment (TME) Tumor hypoxia relief Chemotherapy
Online Erişim:	http://www.sciencedirect.com/science/article/pii/S2590006425007999
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