Self-silencing adenovirus enables precise infectious titration of recombinant adeno-associated viral vectors

Robust and accurate quantification of recombinant adeno-associated virus (rAAV) vectors’ infectivity is essential for pre-clinical and clinical development of AAV gene therapy programs. The industry standard method for rAAV titration is the 50% tissue culture infectious dose (TCID50) assay using HeL...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chloé Fustinoni, Xiang Liu, Zhi Chen, Ryan Cawood, Weimin Valenti, Maria I. Patrício, Weiheng Su
Format: Artigo
Langue:Inglês
Publié: Elsevier 2025-06-01
Collection:Molecular Therapy: Methods & Clinical Development
Sujets:
rAAV
infectious titer
TCID50
TESSA
TREAT assay
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S2329050125000877
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