Self-silencing adenovirus enables precise infectious titration of recombinant adeno-associated viral vectors

Robust and accurate quantification of recombinant adeno-associated virus (rAAV) vectors’ infectivity is essential for pre-clinical and clinical development of AAV gene therapy programs. The industry standard method for rAAV titration is the 50% tissue culture infectious dose (TCID50) assay using HeL...

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Main Authors: Chloé Fustinoni, Xiang Liu, Zhi Chen, Ryan Cawood, Weimin Valenti, Maria I. Patrício, Weiheng Su
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2025-06-01
Series:Molecular Therapy: Methods & Clinical Development
Assuntos:
rAAV
infectious titer
TCID50
TESSA
TREAT assay
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2329050125000877
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