MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma

BackgroundHepatocellular carcinoma (HCC) remains difficult to treat, and molecular determinants that link malignant behavior to the innate immune microenvironment are still needed.MethodsWe integrated two-sample Mendelian randomization using cis-eQTL and cis-pQTL instruments with tumor transcriptomi...

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Auteurs principaux:	Xiuqin An, Yanfang Gao, Shangyumeng Zhao, Wei He, Xinda Yang, Yujie Wu, Jihao Li, Runxi Yi, Yue Han, Mingxuan Li, Qiusheng Li, Ting Yang
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2026-05-01
Collection:	Frontiers in Immunology
Sujets:	complement hepatocellular carcinoma innate immunity macrophages MAPRE2 Mendelian randomization
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1849407/full
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