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MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma

BackgroundHepatocellular carcinoma (HCC) remains difficult to treat, and molecular determinants that link malignant behavior to the innate immune microenvironment are still needed.MethodsWe integrated two-sample Mendelian randomization using cis-eQTL and cis-pQTL instruments with tumor transcriptomi...

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Main Authors: Xiuqin An, Yanfang Gao, Shangyumeng Zhao, Wei He, Xinda Yang, Yujie Wu, Jihao Li, Runxi Yi, Yue Han, Mingxuan Li, Qiusheng Li, Ting Yang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-05-01
Series:Frontiers in Immunology
Subjects:
complement
hepatocellular carcinoma
innate immunity
macrophages
MAPRE2
Mendelian randomization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1849407/full
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