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Selective pressure mediated by influenza virus M158–66 epitope-specific CD8+ T cells promotes accumulation of extra-epitopic amino acid substitutions associated with viral resistance to these T cells

Influenza viruses are notorious for their capacity to evade host immunity. Not only can they evade recognition by virus-neutralizing antibodies, there is also evidence that they accumulate mutations in epitopes recognized by virus-specific CD8+ T cells. In addition, we have shown previously that hum...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Janina M. Jansen, Robert Meineke, Antonia Molle, Carolien E. van de Sandt, Giulietta Saletti, Guus F. Rimmelzwaan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-05-01
Schriftenreihe:Virus Research
Schlagworte:
Influenza virus
T cells
Immune evasion
Mutation
Epitope
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S0168170224000480
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