Divalent HIV-1 gp120 Immunogen Exhibits Selective Avidity for Broadly Neutralizing Antibody VRC01 Precursors

Background: A major goal for the vaccine field is the elicitation of broadly neutralizing antibodies (bnAbs) against pathogens that exhibit extensive antigenic diversity. Methods: In this study, we designed a rigid divalent immunogen for high avidity binding to the bnAb, VRC01, which targets the CD4...

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Detalhes bibliográficos

Principais autores:	Ryan Bailey, Kalista Kahoekapu, Albert To, Ludwig I. Mayerlen, Helmut Kae, Gabriel Manninen, Brien K. Haun, John M. Berestecky, Cecilia Shikuma, Axel T. Lehrer, Iain S. MacPherson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-01-01
coleção:	Vaccines
Assuntos:	HIV vaccine immune focusing germline targeting broadly neutralizing antibodies VRC01
Acesso em linha:	https://www.mdpi.com/2076-393X/14/1/58
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