APOE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes
Abstract Apolipoprotein E4 (APOE4) is the strongest risk allele associated with the development of late onset Alzheimer’s disease (AD). Across the CNS, astrocytes are the predominant expressor of APOE while also being critical mediators of neuroinflammation and cerebral metabolism. APOE4 has been co...
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| Автори: | , , , , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
BMC
2026-02-01
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| Серія: | Journal of Neuroinflammation |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1186/s12974-026-03698-2 |
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