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APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

Abstract Background Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer’s disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest genetic predictor of late-onset AD. While this clinical feature has be...

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Furkejuvvon:
Váldodahkkit: Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, David J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E. A. Young, Jude C. Kluemper, Gabriela Hernandez, Elizabeth J. Allenger, Rachel Mooney, Lesley R. Golden, Cathryn T. Smith, J. Anthony Brandon, Vedant A. Gupta, Philip A. Kern, Matthew S. Gentry, Josh M. Morganti, Ramon C. Sun, Lance A. Johnson
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2021-09-01
Ráidu:Molecular Neurodegeneration
Fáttát:
APOE
Apolipoprotein E
Aerobic glycolysis
Energy expenditure
Metabolism
Alzheimer’s disease
Liŋkkat:https://doi.org/10.1186/s13024-021-00483-y
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