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Effects of the Combination of the <i>C1473G</i> Mutation in the <i>Tph2</i> Gene and <i>Lethal Yellow</i> Mutations in the <i>Raly-Agouti</i> Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice

Tryptophan hydroxylase 2 (TPH2) is the key and rate-limited enzyme of serotonin (5-HT) synthesis in the brain. The <i>C1473G</i> mutation in the <i>Tph2</i> gene results in a two-fold decrease in enzyme activity in the mouse brain. The <i>lethal yellow</i> (<i>A<sup>Y</sup></i>) mutation in the <i>R...

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Gespeichert in:
Hauptverfasser: Polyna D. Komleva, Ghofran Alhalabi, Arseniy E. Izyurov, Nikita V. Khotskin, Alexander V. Kulikov
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2023-06-01
Schriftenreihe:Biomolecules
Schlagworte:
serotonin system
melanocortin system
tryptophan hydroxylase 2
agouti
C1473G polymorphism
lethal yellow
Online-Zugang:https://www.mdpi.com/2218-273X/13/6/963
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