In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2

Tryptophan hydroxylase 2 (TPH2) is the key and rate-limiting enzyme of serotonin (5-HT) synthesis in the mammalian brain. The 1473G mutation in the Tph2 gene decreases TPH2 activity in the mouse brain by twofold. (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one (BH<sub>...

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Bibliografische gegevens

Hoofdauteurs:	Alla B. Arefieva, Polina D. Komleva, Vladimir S. Naumenko, Nikita V. Khotskin, Alexander V. Kulikov
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2023-09-01
Reeks:	Biomolecules
Onderwerpen:	serotonin tryptophan hydroxylase 2 tetrahydrobiopterin thermal stability behavior brain
Online toegang:	https://www.mdpi.com/2218-273X/13/10/1458
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