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Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU

Abstract Background Chemotherapy is a primary treatment for cancer, but its efficacy is often limited by cancer-associated bacteria (CAB) that impair tumor suppressor functions. Our previous research found that Mycoplasma fermentans DnaK, a chaperone protein, impairs p53 activities, which are essent...

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Hoofdauteurs: Francesca Benedetti, Emmanuel F. Mongodin, Jonathan H. Badger, Arshi Munawwar, Ashley Cellini, Weirong Yuan, Giovannino Silvestri, Carl N. Kraus, Simone Marini, Chozha V. Rathinam, Marco Salemi, Hervé Tettelin, Robert C. Gallo, Davide Zella
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2024-03-01
Reeks:Journal of Translational Medicine
Onderwerpen:
DnaK
Mycoplasma
Fusobacterium
Cisplatin
5FU
TCGA
Online toegang:https://doi.org/10.1186/s12967-024-05078-x
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