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Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU

Abstract Background Chemotherapy is a primary treatment for cancer, but its efficacy is often limited by cancer-associated bacteria (CAB) that impair tumor suppressor functions. Our previous research found that Mycoplasma fermentans DnaK, a chaperone protein, impairs p53 activities, which are essent...

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Kaydedildi:
Asıl Yazarlar: Francesca Benedetti, Emmanuel F. Mongodin, Jonathan H. Badger, Arshi Munawwar, Ashley Cellini, Weirong Yuan, Giovannino Silvestri, Carl N. Kraus, Simone Marini, Chozha V. Rathinam, Marco Salemi, Hervé Tettelin, Robert C. Gallo, Davide Zella
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2024-03-01
Seri Bilgileri:Journal of Translational Medicine
Konular:
DnaK
Mycoplasma
Fusobacterium
Cisplatin
5FU
TCGA
Online Erişim:https://doi.org/10.1186/s12967-024-05078-x
Etiketler: Etiketle
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