Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-induced generation of ROS increases integrin adhesion...

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Bibliografische Detailangaben

Hauptverfasser:	Marius C. Staiculescu, Francisco I. Ramirez-Perez, Jorge A. Castorena-Gonzalez, Zhongkui eHong, Zhe eSun, Gerald A. Meininger, Luis A. Martinez-Lemus
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2014-10-01
Schriftenreihe:	Frontiers in Physiology
Schlagworte:	Integrin activation myogenic response fibronectin reactive oxygen species (ROS) focal adhesion basal tone
Online-Zugang:	http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00413/full
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