Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-induced generation of ROS increases integrin adhesion...

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Autori principali:	Marius C. Staiculescu, Francisco I. Ramirez-Perez, Jorge A. Castorena-Gonzalez, Zhongkui eHong, Zhe eSun, Gerald A. Meininger, Luis A. Martinez-Lemus
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2014-10-01
Serie:	Frontiers in Physiology
Soggetti:	Integrin activation myogenic response fibronectin reactive oxygen species (ROS) focal adhesion basal tone
Accesso online:	http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00413/full
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