Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin and found that myelin lamellae are broken down...

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主要な著者:	Marie-Theres Weil, Wiebke Möbius, Anne Winkler, Torben Ruhwedel, Claudia Wrzos, Elisa Romanelli, Jeffrey L. Bennett, Lukas Enz, Norbert Goebels, Klaus-Armin Nave, Martin Kerschensteiner, Nicole Schaeren-Wiemers, Christine Stadelmann, Mikael Simons
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2016-07-01
シリーズ:	Cell Reports
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124716307276
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