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Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

In the central nervous system (CNS), myelin formation and repair are regulated by oligodendrocyte (OL) lineage cells, which sense and integrate signals from their environment, including from other glial cells and the extracellular matrix (ECM). The signaling pathways that coordinate this complex com...

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Principais autores: Stefanie Giera, Rong Luo, Yanqin Ying, Sarah D Ackerman, Sung-Jin Jeong, Hannah M Stoveken, Christopher J Folts, Christina A Welsh, Gregory G Tall, Beth Stevens, Kelly R Monk, Xianhua Piao
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2018-05-01
Serier:eLife
Fag:
oligodendrocyte
microglia
myelination
remyelination
Online adgang:https://elifesciences.org/articles/33385
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