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Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

Abstract Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes infection is regulated by an interplay between human STING genotype...

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Автори: Elin Movert, Jaume Salgado Bolarin, Christine Valfridsson, Jorge Velarde, Steinar Skrede, Michael Nekludov, Ole Hyldegaard, Per Arnell, Mattias Svensson, Anna Norrby-Teglund, Kyu Hong Cho, Eran Elhaik, Michael R. Wessels, Lars Råberg, Fredric Carlsson
Формат: Artigo
Мова:Inglês
Опубліковано: Nature Portfolio 2023-07-01
Серія:Nature Communications
Онлайн доступ:https://doi.org/10.1038/s41467-023-39771-0
Теги: Додати тег
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