Cytosolic serpins act in a cytoprotective feedback loop that limits ESX-1-dependent death of Mycobacterium marinum-infected macrophages

ABSTRACT Serine protease inhibitors (serpins) constitute the largest family of protease inhibitors expressed in humans, but their role in infection remains largely unexplored. In infected macrophages, the mycobacterial ESX-1 type VII secretion system permeabilizes internal host membranes and causes...

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Detalhes bibliográficos

Principais autores:	Esther Nobs, Katie Laschanzky, Kristina Munke, Elin Movert, Christine Valfridsson, Fredric Carlsson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2024-09-01
coleção:	mBio
Assuntos:	bacterial pathogenesis host cell death membrane permeabilization cytosolic surveillance pathways type VII secretion system host-pathogen interactions
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.00384-24
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