The Critical Role of The Piezo1/β‐catenin/ATF4 Axis on The Stemness of Gli1+ BMSCs During Simulated Microgravity‐Induced Bone Loss

Abstract Disuse osteoporosis is characterized by decreased bone mass caused by abnormal mechanical stimulation of bone. Piezo1 is a major mechanosensitive ion channel in bone homeostasis. However, whether intervening in the action of Piezo1 can rescue disuse osteoporosis remains unresolved. In this...

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Autores principales:	Yuxiang Hu, Hongtao Tian, Wei Chen, Yunlu Liu, Yulin Cao, Hongxin Pei, Chaochang Ming, Cunqing Shan, Xihui Chen, Zhipeng Dai, Shuhua Yang, Zengwu Shao, Shenghui Lan, Yong Liu, Wei Tong
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2023-11-01
Colección:	Advanced Science
Materias:	Piezo1 simulated microgravity disuse osteoporosis Gli1+ BMSCs Wnt/β‐catenin/ATF4
Acceso en línea:	https://doi.org/10.1002/advs.202303375
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