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The Critical Role of The Piezo1/β‐catenin/ATF4 Axis on The Stemness of Gli1+ BMSCs During Simulated Microgravity‐Induced Bone Loss

Abstract Disuse osteoporosis is characterized by decreased bone mass caused by abnormal mechanical stimulation of bone. Piezo1 is a major mechanosensitive ion channel in bone homeostasis. However, whether intervening in the action of Piezo1 can rescue disuse osteoporosis remains unresolved. In this...

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Principais autores: Yuxiang Hu, Hongtao Tian, Wei Chen, Yunlu Liu, Yulin Cao, Hongxin Pei, Chaochang Ming, Cunqing Shan, Xihui Chen, Zhipeng Dai, Shuhua Yang, Zengwu Shao, Shenghui Lan, Yong Liu, Wei Tong
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2023-11-01
Serier:Advanced Science
Fag:
Piezo1
simulated microgravity
disuse osteoporosis
Gli1+ BMSCs
Wnt/β‐catenin/ATF4
Online adgang:https://doi.org/10.1002/advs.202303375
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