An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

The Hedgehog signaling pathway is part of the ancient developmental-evolutionary animal toolkit. Frequently co-opted to pattern new structures, the pathway is conserved among eumetazoans yet flexible and pleiotropic in its effects. The Hedgehog receptor, Patched, is transcriptionally activated by He...

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Bibliographic Details

Main Authors:	David S Lorberbaum, Andrea I Ramos, Kevin A Peterson, Brandon S Carpenter, David S Parker, Sandip De, Lauren E Hillers, Victoria M Blake, Yuichi Nishi, Matthew R McFarlane, Ason CY Chiang, Judith A Kassis, Benjamin L Allen, Andrew P McMahon, Scott Barolo
Format:	Artigo
Language:	Inglês
Published:	eLife Sciences Publications Ltd 2016-05-01
Series:	eLife
Subjects:	gene regulation evolution of development (evo-devo) Hedgehog signaling cis-regulatory elements transcriptional regulation development
Online Access:	https://elifesciences.org/articles/13550
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