Refined Design and Liquid-Phase Assembly of GalNAc-siRNA Conjugates: Comparative Efficiency Validation in PCSK9 Targeting

The development and application of therapeutic oligonucleotides, such as siRNA, miRNA, ASOs and aptamers, is a rapidly growing field in biomedicine. These molecules are undergoing extensive preclinical and clinical testing, and the market for synthetic RNA drugs is expanding. However, several challe...

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Detalhes bibliográficos

Principais autores:	Nikolai A. Dmitriev, Petr V. Chernov, Ivan S. Gongadze, Valeriia I. Kovchina, Vladimir N. Ivanov, Artem E. Gusev, Igor P. Shilovskiy, Ilya A. Kofiadi, Musa R. Khaitov
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-01-01
coleção:	Molecules
Assuntos:	RNAi siRNA GalNAc <i>PCSK9</i> hypercholesterolemia liquid-phase conjugation
Acesso em linha:	https://www.mdpi.com/1420-3049/31/3/476
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