In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells

Abstract Three years after SARS-CoV-2 emerged as a global infectious threat, the virus has become endemic. The neurological complications such as depression, anxiety, and other CNS complications after COVID-19 disease are increasing. The brain, and CSF have been shown as viral reservoirs for SARS-Co...

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Principais autores:	Sean N. Avedissian, Johid R. Malik, Anthony T. Podany, Michael Neely, Nathaniel J. Rhodes, Kimberly K. Scarsi, Marc H. Scheetz, Michael J. Duryee, Ukamaka O. Modebelu, Timothy M. Mykris, Lee C. Winchester, Siddappa N. Byrareddy, Courtney V. Fletcher
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-05-01
coleção:	Scientific Reports
Assuntos:	Nirmatrelvir/ritonavir Blood–brain-barrier Central nervous system
Acesso em linha:	https://doi.org/10.1038/s41598-024-60935-5
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