Effect of cAMP signaling on expression of glucocorticoid receptor, Bim and Bad in glucocorticoid-sensitive and resistant leukemic and multiple myeloma cells

Stimulation of cAMP signaling induces apoptosis in glucocorticoid-sensitive and resistant CEM leukemic and MM.1 multiple myeloma cell lines, and this effect is enhanced by dexamethasone in both glucocorticoid-sensitive cell types and in glucocorticoid-resistant CEM cells. Expression of the mRNA for...

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Hauptverfasser:	Hongli eDong, Michael E. Carlton, Adam eLerner, Paul Mark Epstein
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2015-10-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	Leukemia Multiple Myeloma phosphodiesterases Bim glucocorticoid receptors BAD
Online-Zugang:	http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00230/full
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