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EGFR-D770>GY and Other Rare EGFR Exon 20 Insertion Mutations with a G770 Equivalence Are Sensitive to Dacomitinib or Afatinib and Responsive to EGFR Exon 20 Insertion Mutant-Active Inhibitors in Preclinical Models and Clinical Scenarios

<i>Epidermal growth factor receptor</i> (<i>EGFR</i>) exon 20 insertion mutations account for a tenth of all <i>EGFR</i> mutations in lung cancers. An important unmet clinical need is the identification of EGFR exon 20 insertion mutants that can respond to multiple classes of approved EGFR-TKIs. We...

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Principais autores: Ikei S. Kobayashi, Hollis Viray, Deepa Rangachari, Susumu S. Kobayashi, Daniel B. Costa
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2021-12-01
סדרה:Cells
נושאים:
lung cancer
EGFR exon 20 insertion
D770&gt;GY
afatinib
dacomitinib
poziotinib
גישה מקוונת:https://www.mdpi.com/2073-4409/10/12/3561
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