Chronic fluoxetine modulates perineuronal nets and inhibitory neuronal function in relation to behavioral outcomes

Chronic fluoxetine administration has been reported to enhance neural plasticity in the adult brain, but the underlying structural correlates remain incompletely understood. In particular, the impact of fluoxetine on aggrecan-positive perineuronal nets (PNNs)—critical regulators of plasticity—is lar...

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Autores principales: Hiroshi Ueno, Eriko Kitano, Sachiko Mori, Yu Takahashi, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2025-12-01
Colección:IBRO Neuroscience Reports
Materias:
Fluoxetine
Neuroplasticity
Perineuronal nets
Aggrecan
Parvalbumin
Behavior
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2667242125001654
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