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Functional equivalence of dihydropyridine receptor a1S and b1a subunits in triggering excitation-contraction coupling in skeletal muscle

Molecular understanding of the mechanism of excitation-contraction (EC) coupling in skeletal muscle has been made possible by cultured myotube models lacking specific dihydropyridine receptor (DHPR) subunits and ryanodine receptor type 1 (RyR1) isoforms. Transient expression of missing cDNAs in muta...

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Principais autores: ROBERTO CORONADO, CHRIS A AHERN, DAVID C SHERIDAN, WEIJUN CHENG, LEAH CARBONNEAU, DIPANKAR BHATTACHARYA
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2004-01-01
coleção:Biological Research
Assuntos:
L-type Ca2+ channel
Ca2+ transients
confocal imaging
cDNA expression
b1 KO myotubes
DHPR voltage sensor
Acesso em linha:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400010
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