Reverse and Forward Electron Flow-Induced H₂O₂ Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals

α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been identified in neurodegenerative diseases such as in Alzheimer’s disease. The aim of the present study was to establish the role of t...

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Detalhes bibliográficos

Principais autores:	Gergő Horváth, Gergely Sváb, Tímea Komlódi, Dora Ravasz, Gergely Kacsó, Judit Doczi, Christos Chinopoulos, Attila Ambrus, László Tretter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-07-01
coleção:	Antioxidants
Assuntos:	KGDHc α-ketoglutarate dehydrogenase complex OGDHc oxoglutarate dehydrogenase complex ischemia-reperfusion antioxidant systems
Acesso em linha:	https://www.mdpi.com/2076-3921/11/8/1487
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