Reverse and Forward Electron Flow-Induced H₂O₂ Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals

α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been identified in neurodegenerative diseases such as in Alzheimer’s disease. The aim of the present study was to establish the role of t...

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Библиографические подробности

Главные авторы:	Gergő Horváth, Gergely Sváb, Tímea Komlódi, Dora Ravasz, Gergely Kacsó, Judit Doczi, Christos Chinopoulos, Attila Ambrus, László Tretter
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2022-07-01
Серии:	Antioxidants
Предметы:	KGDHc α-ketoglutarate dehydrogenase complex OGDHc oxoglutarate dehydrogenase complex ischemia-reperfusion antioxidant systems
Online-ссылка:	https://www.mdpi.com/2076-3921/11/8/1487
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