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A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective Autophagy via the PDK1/Akt Signaling Pathway in Non-Small Cell Lung Cancer

In a preliminary study, we synthesized a series of new PDK1/MEK dual inhibitors. Antitumor activity screening showed that Compound YZT exerts a strong inhibitory action in A549 cells. However, the specific mechanism of YZT against non-small cell lung cancer (NSCLC) is largely unknown. This work conf...

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Principais autores: Rangru Liu, Zhuo Chen, Gaoyun Hu, Zutao Yu, Qianbin Li, Danqi Liu, Ling Li, Zhaoqian Liu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-02-01
coleção:Pharmaceuticals
Assuntos:
compound YZT
a PDK1/MEK dual inhibitor
the PDK1/Akt pathway
autophagy
apoptosis
Acesso em linha:https://www.mdpi.com/1424-8247/16/2/244
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