A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective Autophagy via the PDK1/Akt Signaling Pathway in Non-Small Cell Lung Cancer

In a preliminary study, we synthesized a series of new PDK1/MEK dual inhibitors. Antitumor activity screening showed that Compound YZT exerts a strong inhibitory action in A549 cells. However, the specific mechanism of YZT against non-small cell lung cancer (NSCLC) is largely unknown. This work conf...

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Hlavní autoři:	Rangru Liu, Zhuo Chen, Gaoyun Hu, Zutao Yu, Qianbin Li, Danqi Liu, Ling Li, Zhaoqian Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-02-01
Edice:	Pharmaceuticals
Témata:	compound YZT a PDK1/MEK dual inhibitor the PDK1/Akt pathway autophagy apoptosis
On-line přístup:	https://www.mdpi.com/1424-8247/16/2/244
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