Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
Biallelic inactivation of the von Hippel-Lindau tumor suppressor gene (VHL) is linked to the development of hereditary (VHL-associated) and sporadic clear-cell renal carcinomas as well as other abnormalities. The VHL gene product, pVHL, is part of an E3 ubiquitin ligase complex that targets the alph...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2003-12-01
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| coleção: | PLoS Biology |
| Acesso em linha: | https://doi.org/10.1371/journal.pbio.0000083 |
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