DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH.

The pro-survival protein Bcl-xL is critical for the resistance of tumour cells to DNA damage. We have previously demonstrated, using a mouse cancer model, that oncogenic tyrosine kinase inhibition of DNA damage-induced Bcl-xL deamidation tightly correlates with T cell transformation in vivo, althoug...

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Autors principals:	Rui Zhao, David Oxley, Trevor S Smith, George A Follows, Anthony R Green, Denis R Alexander
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2007-01-01
Col·lecció:	PLoS Biology
Accés en línia:	https://doi.org/10.1371/journal.pbio.0050001
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