Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3.

Cytotoxic T lymphocytes (CTLs) are the major killer of virus-infected cells. Granzyme B (GrB) from CTLs induces apoptosis in target cells by cleavage and activation of substrates like caspase-3 and Bid. However, while undergoing apoptosis, cells are still capable of producing infectious viruses unle...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Marcelo Marcet-Palacios, Brenda Lee Duggan, Irene Shostak, Michele Barry, Tracy Geskes, John A Wilkins, Akiko Yanagiya, Nahum Sonenberg, R Chris Bleackley
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Public Library of Science (PLoS) 2011-12-01
Rangatū:	PLoS Pathogens
Urunga tuihono:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22194691/?tool=EBI
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!