Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1

Abstract FKS1 is a β−1,3-glucan synthase critical for fungal cell wall formation and a target for antifungal drugs such as echinocandin and ibrexafungerp. However, the mechanisms regulating FKS1 activity remain largely unknown. Here, we reveal that transfer RNA (tRNA) acts as an endogenous inhibitor...

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Autores principales:	Jialu Li, Jian Li, Angqi Zhu, Xinli Dai, Juxiu Liu, Huayi Liu, Zhili Xia, Yuefan Dong, Wenyu Qian, Lunzhi Dai, Li Guo, Chuangye Yan, Dong Deng, Yunzi Luo, Xiang Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-12-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-025-67293-4
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