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RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin

RhoA-GTPase (RhoA) is widely regarded as a key molecular switch to inhibit neurite outgrowth by rigidifying the actin cytoskeleton. However, during neurite outgrowth, whether and how microtubule dynamics are regulated by RhoA remains to be elucidated. Herein, CT04 and Y27632 were used to inactivate...

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Principais autores: Dandan Tan, Haowen Zhang, Junyao Deng, Jingmin Liu, Jinkun Wen, Lixia Li, Xianghai Wang, Mengjie Pan, Xiaofang Hu, Jiasong Guo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-01-01
coleção:Cells
Assuntos:
neurite outgrowth
rhoa signaling pathway
spastin
p60-katanin
microtubule-severing proteins
glu-tubulin
Acesso em linha:https://www.mdpi.com/2073-4409/9/1/230
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